UEFA has now confirmed the dates and times for the League Phase fixtures of this season's Champions League.
This is what awaits Napoli:
| Matchday | Fixture | Date | Stadium |
| 1 | Manchester City v Napoli | 18 September 2025 - 21:00 | Etihad Stadium |
| 2 | Napoli v Sporting Club de Portugal | 1 October 2025 - 21:00 | Diego Armando Maradona |
| 3 | PSV v Napoli | 21 October 2025 - 21:00 | Philips Stadion |
| 4 | Napoli v Eintracht | 4 November 2025 - 18:45 | Diego Armando Maradona |
| 5 | Napoli v Qarabag | 25 November 2025 - 21:00 | Diego Armando Maradona |
| 6 | Benfica v Napoli | 10 December 2025 - 21:00 | Estadio da Luz |
| 7 | FC Copenhagen v Napoli | 20 January 2026 - 21:00 | Parken |
| 8 | Napoli v Chelsea | 28 January 2026 - 21:00 | Diego Armando Maradona |
